What to Watch Thursday 9/25: 'How to Get Away with Murder' series premiere; 'Grey's Anatomy,' 'Scandal' season premieres

Tonight catch the series premiere of How to Get Away with Murder and season premieres of Grey's Anatomy and Scandal. Plus all new episodes of The Biggest Loser and Project Runway.

What to Watch: Thursday, September 25

8:00pm: Grey's Anatomy, ABC (1 hr) SEASON PREMIERE

Callie and Arizona make a big choice about surrogacy, Amelia uncovers a secret and Bailey and Alex fight for Cristina's vacated seat on the Board.

8:00pm: The Biggest Loser, NBC (2 hrs) NEW

The contestants test their nutrional knowledge and create an inspiration wall to remind them of their goals and help them get there. This season's cast features out trainer Bob Harper.

9:00pm: Scandal, ABC (1 hr) SEASON PREMIERE

Fitz begins his second term as Mellie struggles to deal with their son's death and Olivia's absence leaves a hole in the Pope & Associate's team.

9:00pm: Project Runway, Lifetime (1.5 hrs) NEW

The contestants pick a random person off the street and must convince them to allow the designer to make them over.

10:00pm: How to Get Away with Murder, ABC (1 hr) SERIES PREMIERE

A defense attorney and law professor picks a handful of her best students to work at her firm, but the group find themselves stuck in the middle of a real murder conspiracy.

This morning and afternoon, check your local listings for information about EllenThe Talk (CBS), The Gossip Table (VH1), The View (ABC) and The Chew (ABC). Soap operas Days of Our Lives on NBC and General Hospital on ABC (check local listings for time) both feature out characters.

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About What to Watch on TV

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