American Dad!
animated comedy
FOX, Sundays, 9:30 PM
http://www.fox.com/americandad/

This animated satire features occasional news reports from co-anchors and domestic partners Greg Corbin (Seth McFarlane) and Terry Bates (Mike Barker, pictured).

The Best Years
drama
The N, Fridays, 9:30 PM
http://www.the-n.com/ntv/shows/index.php?id=654

This new drama follows the life of a college freshman attending a prestigious university in Boston. Providing a dash of gay culture is Lee Campbell (Alan Van Spring), the owner of the local hotspot where the gang hangs out.

Brotherhood
drama
Showtime, returns in fall
http://www.sho.com/site/brotherhood/home.do

Alex (Karl Bury, pictured) is politician Tommy Caffee's (Jason Clarke) chief of staff.

The Business
comedy
IFC, Sundays, 11 PM
http://ifc.com/series?aId=17962

After last year's indie film successes, Vic's Flicks returns with new offices and a new five-year plan. Terrance (Matt Silver) works in the animation division and just recently came out.

Dirty Sexy Money
drama
ABC, Wednesdays, 10 PM
http://abc.go.com/fallpreview/dirtysexymoney/index

Among the siblings of the Darling clan is New York District Attorney Patrick, who's carrying on a secret relationship with the transgender Carmelita (Candis Cayne).

ER
drama
NBC
Thursdays, 10 PM
http://www.nbc.com/ER/

Chaz Pratt (Sam Jones III) the gay half-brother of Dr. Gregory Pratt (Mekhi Phifer). The hospital is soon set to introduce a new gay, Latino desk clerk named Javier (Jesse Borrego.)

Friday Night Lights
drama
NBC, Wednesdays, 8 PM
http://www.nbc.com/Friday_Night_Lights/

Lucy Rodell (Libby Villari) is the closeted Mayor of Dillon, Texas.

Grey's Anatomy
drama
ABC, Thursdays, 9 PM
http://abc.go.com/primetime/greysanatomy/index.html

All the interns of Seattle Grace Hospital hang out at Emerald City Bar, owned by gay bartender Joe (Steven W. Bailey), who recently adopted a child with Walter, his partner.

The Minor Accomplishments of Jackie Woodman
comedy
IFC, Sundays, 11:30 PM
http://ifc.com/

Jackie Woodman (Laura Kightlinger) is an aspiring screenwriter who writes for a second-rate magazine called Image, where Mitchell (Patrick Bristow, pictured), a gay writer, works. Connor (Butch Klein) is Jackie's best friend's closeted boyfriend.

The Simpsons
animated comedy
Fox, Sundays, 8 PM
http://www.thesimpsons.com/

Springfield houses lesbian and gay citizens, including Marge's sister, Patty Bouvier (Julie Kavner, left), and Waylon Smithers (Harry Shearer, right).

The Tudors
drama
Showtime, Returns in 2008
http://www.sho.com/site/tudors/home.do

The bodice-busting dramatic series set in the court of Henry IIIV (Jonathan Ryhs Myers), also features composer Thomas Tallis (Joe Van Moyland) , whose male lover died last season.

Weeds
comedy
Showtime, Returns in June
http://www.sho.com/site/weeds/home.do

Young Isabelle (Allie Grant, left) has told her mother Celia (Elizabeth Perkins), that she's a lesbian. Sanjay (Maulik Pancholy, right) has recently come out of the closet as well.